Hamilton High School may refer to:
- Hamilton High School (Alabama) in Hamilton
- Hamilton High School (Chandler, Arizona) in Chandler
- Lake Hamilton High School in Pearcy
- Hamilton High School (Anza, California)
- Hamilton Union High School in Hamilton City
- Alexander Hamilton High School (Los Angeles)
- Hamilton High School (Scottdale, Georgia) in Dekalb County; served African American students until desegregation in 1969
- Hamilton-Wenham Regional High School in South Hamilton
- Hamilton High School (Michigan) in Hamilton
- Hamilton High School (Montana) in Hamilton
In Hamilton Township, Mercer County:
- Hamilton High School East, or Steinert High School
- Hamilton High School North, or Nottingham High School
- Hamilton High School West, or Hamilton High School
- Alexander Hamilton Jr./Sr. High School in Elmsford
- Alexander Hamilton High School (Brooklyn) in Brooklyn
- Fort Hamilton High School in Brooklyn
- Hamilton High School (Hamilton, Ohio)
- Hamilton Catholic High School in Hamilton
- Hamilton Township High School in Columbus
- Hamilton High School (Texas) in Hamilton
- The false name given to the high school in The World We Created at Hamilton High, a 1988 non-fiction book by Gerald Grant
- Hamilton High School, New Zealand, later split into two single-sex schools
- Hamilton Boys' High School in Hamilton
- Hamilton Girls' High School in Hamilton