RDS-127


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RDS-127は、科学研究に用いられる薬剤である。D2様受容体のアゴニストとして作用し[1]、またセロトニンおよびドーパミン受容体作動薬（英語版）[2][3][4][5]、抗コリン薬としての性質も持つ[6][7]。動物実験では、食欲抑制薬（英語版）および催淫薬の両方の効果を示す[8][9]。

RDS-127
IUPAC命名法による物質名
  • 4,7-dimethoxy-N,N-dipropyl-2,3-dihydro-1H-inden-2-amine
識別
CAS番号
 82668-32-4 チェック
ATCコード none
PubChem CID: 134064
ChemSpider 118214 ×
化学的データ
化学式C17H27NO2
分子量277.402 g/mol
  • CCCN(CCC)C1CC2=C(C=CC(=C2C1)OC)OC
  • InChI=1S/C17H27NO2/c1-5-9-18(10-6-2)13-11-14-15(12-13)17(20-4)8-7-16(14)19-3/h7-8,13H,5-6,9-12H2,1-4H3 ×
  • Key:FPAHQTSJKYIURQ-UHFFFAOYSA-N ×
テンプレートを表示
  1. ^ Arnerić SP, Long JP, Williams M, et al. (January 1983). “RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane): central effects of a new dopamine receptor agonist”. The Journal of Pharmacology and Experimental Therapeutics 224 (1): 161–70. PMID 6401334.
  2. ^ Arnerić SP, Roetker A, Long JP, Mott J, Barfknecht CF (June 1982). “Effects of semirigid methoxamine analogs on vascular smooth muscle: studies of methoxy-2-aminotetralin and 2-aminoindane derivatives”. Archives Internationales De Pharmacodynamie et De Thérapie 257 (2): 263–73. PMID 7114973.
  3. ^ Arnerić SP, Long JP (May 1984). “Evidence that a novel dopamine receptor agonist, RDS-127 [2-di-n-propylamino-4,7-dimethoxyindane] has some centrally mediated cardiovascular actions”. The Journal of Pharmacy and Pharmacology 36 (5): 318–21. doi:10.1111/j.2042-7158.1984.tb04382.x. PMID 6145768.
  4. ^ Clark JT, Smith ER (1986). “Failure of pimozide and metergoline to antagonize the RDS-127-induced facilitation of ejaculatory behavior”. Physiology & Behavior 37 (1): 47–52. doi:10.1016/0031-9384(86)90382-3. PMID 3737722.
  5. ^ Rezaki YE, Ilhan M (1991). “Evaluation of alpha-adrenoceptor agonistic activity of RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane) in rabbit and rat aortae”. Archives Internationales De Pharmacodynamie et De Thérapie 310: 76–86. PMID 1685313.
  6. ^ Sahin I, Ilhan M (1988). “The antimuscarinic activity of a dopamine receptor agonist (RDS-127) differentiates M2-muscarinic receptors of heart, ileum and trachea in guinea-pig”. Archives Internationales De Pharmacodynamie et De Thérapie 296: 163–72. PMID 2907277.
  7. ^ Sahin I, Tuncer M, Ilhan M (March 1990). “Dopamine receptor agonists, N,N-dipropyl-2-aminotetralin (TL-68) and 2-di-n-propylamino-4,7-dimethoxyindane (RDS-127) antagonize oxotremorine-induced tremors by antimuscarinic action in mice”. Archives Internationales De Physiologie et De Biochimie 98 (1): 7–9. doi:10.3109/13813459009115730. PMID 1692697.
  8. ^ Arnerić SP, Roetker A, Long JP (September 1982). “Potent anorexic-like effects of RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane) in the rat: a comparison with other dopamine-receptor agonists”. Neuropharmacology 21 (9): 885–90. doi:10.1016/0028-3908(82)90080-6. PMID 6897285.
  9. ^ Kwong LL, Smith ER, Davidson JM, Peroutka SJ (October 1986). “Differential interactions of "prosexual" drugs with 5-hydroxytryptamine1A and alpha 2-adrenergic receptors”. Behavioral Neuroscience 100 (5): 664–8. doi:10.1037/0735-7044.100.5.664. PMID 2877677.