Creatine: Difference between revisions - Wikipedia

Line 160:

A 2018 [[systematic review]] found that "generally, there was evidence that short term memory and intelligence/reasoning may be improved by creatine administration", whereas for other cognitive domains "the results were conflicting".<ref>{{cite journal |title=Effects of creatine supplementation on cognitive function of healthy individuals: A systematic review of randomized controlled trials |journal=[[Experimental Gerontology]] |date=2018 |volume=108 |pages=166–173 |pmc=6093191 |last1=Avgerinos |first1=K. I. |last2=Spyrou |first2=N. |last3=Bougioukas |first3=K. I. |last4=Kapogiannis |first4=D. |doi=10.1016/j.exger.2018.04.013 |pmid=29704637 }}</ref> Another 2023 review initially found evidence of improved memory function.<ref>{{cite journal |title=Effects of creatine supplementation on memory in healthy individuals: a systematic review and meta-analysis of randomized controlled trials |journal=[[Nutrition Reviews]] |date=2023 |volume=81 |issue=4 |pages=416–27 |doi=10.1093/nutrit/nuac064 |pmid=35984306 |last1=Prokopidis |first1=Konstantinos |last2=Giannos |first2=Panagiotis |last3=Triantafyllidis |first3=Konstantinos K. |last4=Kechagias |first4=Konstantinos S. |last5=Forbes |first5=Scott C. |last6=Candow |first6=Darren G. |pmc=9999677 }}</ref> However, it was later determined that faulty statistics lead to the statistical significance and after fixing the "double counting", the effect was only significant in older adults.<ref>{{cite journal |last1=Prokopidis |first1=Konstantinos |last2=Giannos |first2=Panagiotis |last3=Triantafyllidis |first3=Konstantinos K |last4=Kechagias |first4=Konstantinos S |last5=Forbes |first5=Scott C |last6=Candow |first6=Darren G |title=Author's reply: Letter to the Editor: Double counting due to inadequate statistics leads to false-positive findings in "Effects of creatine supplementation on memory in healthy individuals: a systematic review and meta-analysis of randomized controlled trials" |journal=Nutrition Reviews |date=16 January 2023 |volume=81 |issue=11 |pages=1497–1500 |doi=10.1093/nutrit/nuac111 |pmid=36644912 |url=https://academic.oup.com/nutritionreviews/advance-article-abstract/doi/10.1093/nutrit/nuac111/6987897?redirectedFrom=fulltext&login=false |access-date=31 August 2023}}</ref>

A 2023 systematic review foundstudy no"...supported evidenceclaims that creatine improvedsupplementation cognitivecan performanceincreases brain creatine content but also demonstrated somewhat equivocal results for effects on cognition. TheIt does, however, provide evidence to suggest that more research is required with stressed populations, as supplementation researchesdoes criticizedappear theto methodologysignificantly ofaffect previousbrain reviewscontent.<ref>{{Cite journal |last1=McMorris |first1=Terry |last2=Hale |first2=Beverley J. |last3=Pine |first3=Beatrice S. |last4=Williams |first4=Thomas B. |date=2024-04-04 |title=Creatine supplementation research fails to support the theoretical basis for an effect on cognition: Evidence from a systematic review |journal=Behavioural Brain Research |volume=466 |pages=114982 |doi=10.1016/j.bbr.2024.114982 |issn=1872-7549 |pmid=38582412|doi-access=free }}</ref>

===Muscular disease===