Article Images
Content deleted Content added
Rjwilmsi 930,992 edits m |
|||
Line 8: It was shown that the [[embryonic stem cell]] (ESC)-specific isoform of FOXP1 stimulates the expression of transcription factor genes required for pluripotency, including [[OCT4]], [[Homeobox protein NANOG|NANOG]], [[NR5A2]], and [[GDF3]], while concomitantly repressing genes required for ESC differentiation. This isoform also promotes the maintenance of ESC pluripotency and contributes to efficient reprogramming of somatic cells into induced pluripotent stem cells. These results reveal a pivotal role for an Alternative splicing event in the regulation of pluripotency through the control of critical ESC-specific transcriptional programs.<ref name="pmid21924763">{{cite journal | author = Gabut M, Samavarchi-Tehrani P, Wang X, Slobodeniuc V, O'Hanlon D, Sung HK, Alvarez M, Talukder S, Pan Q, Mazzoni EO, Nedelec S, Wichterle H, Woltjen K, Hughes TR, Zandstra PW, Nagy A, Wrana JL, Blencowe BJ | title = An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming | journal = Cell | volume = 147 | issue = 1 | pages = 132–46 |date=September 2011 | pmid = 21924763 | doi = 10.1016/j.cell.2011.08.023 }}</ref> The expression of FOXP1 was also implicated in the biology of B cell malignancies, and is regulated by by non-coding RNA (miRNA) termed miR-150. <ref>{{Cite pmid|24787006}}</ref> ==See also== | |||