GABAA-rho receptor: Difference between revisions - Wikipedia
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Line 67: == Function == In addition to containing a GABA binding site, the GABA<sub>A</sub>-ρ receptor complex conducts [[chloride]] ions across neuronal [[cell membrane|membrane]]s. Binding of GABA to the receptor results in opening of this channel. When the [[reversal potential]] of chloride is less than the membrane potential, chloride ions flow down their [[electrochemical gradient]] into the cell. This influx of chloride ions lowers the [[membrane potential]] of (hyperpolarizes) the neuron, making it more difficult for these cells to conduct electrical impulses in the form of an action potential. Following stimulation by GABA, the chloride current produced by GABA<sub>A</sub>-ρ receptors is slow to initiate but sustained in duration. In contrast, the GABA<sub>A</sub> receptor current has a rapid onset and short duration. GABA is about 10 times more potent at GABA<sub>A</sub>-ρ than it is at most GABA<sub>A</sub> receptors. == Structure == Line 108: == Genetics == In humans, GABA<sub>A</sub>-ρ receptor subunits ρ1 and ρ2 are [[code for|encoded by]] the {{Gene|GABRR1}} and {{Gene|GABRR2}} [[gene]]s which are found on [[Chromosome 6 (human)|chromosome 6]] whereas the {{Gene|GABRR3}} gene for ρ3 is found on [[Chromosome 3 (human)|chromosome 3]] == References == | |||