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#REDIRECT[[gasotransmitter]]
{{AFC submission|r||u=Zebrafishgroup|ns=118|reviewer=Aviram7|reviewts=20231207170622|ts=20231205224906}} <!-- Do not remove this line! -->
{{Short description|Gasotransmitter-based cell signaling}}
{{Draft topics|chemistry}}
{{AfC topic|stem}}
The gasocrine<ref>{{cite journal |last1=Anbalagan |first1=Savani |title=Endocrine cross‐talk between the gut microbiome and glial cells in development and disease |journal=Journal of Neuroendocrinology |date=May 2021 |volume=33 |issue=5 |doi=10.1111/jne.12924}}</ref><ref>{{cite journal |last1=Anbalagan |first1=Savani |title=Arguments for gasocrine signaling |journal=OSF Preprints |date=1 December 2023 |doi=10.31219/osf.io/fe85j}}</ref> system is a messenger system in an [[organism]] based on [[Gasotransmitter|gasotransmitters]] that are [[secretion|released]] by [[Cell (biology)|cells]] and act at a distant cell either directly or in [[Metabolism|metabolized]] forms.
== Examples ==
An example of gasocrine signal is [[Nitric oxide]] (NO). NO overexpression in mice heart leads to significant increases in NO metabolites: [[nitrite]], [[nitrate]], and nitrosothiols in distant tissues and mediates [[Cytoprotection|cytoprotection]].<ref>{{cite journal |last1=Elrod |first1=John W. |last2=Calvert |first2=John W. |last3=Gundewar |first3=Susheel |last4=Bryan |first4=Nathan S. |last5=Lefer |first5=David J. |title=Nitric oxide promotes distant organ protection: Evidence for an endocrine role of nitric oxide |journal=Proceedings of the National Academy of Sciences |date=12 August 2008 |volume=105 |issue=32 |pages=11430–11435 |doi=10.1073/pnas.0800700105}}</ref><ref>{{cite journal |last1=Bahadoran |first1=Zahra |last2=Carlström |first2=Mattias |last3=Mirmiran |first3=Parvin |last4=Ghasemi |first4=Asghar |title=Nitric oxide: To be or not to be an endocrine hormone? |journal=Acta Physiologica |date=May 2020 |volume=229 |issue=1 |doi=10.1111/apha.13443}}</ref><ref>{{cite journal |last1=Bryan |first1=Nathan S |last2=Fernandez |first2=Bernadette O |last3=Bauer |first3=Selena M |last4=Garcia-Saura |first4=Maria Francisca |last5=Milsom |first5=Alexandra B |last6=Rassaf |first6=Tienush |last7=Maloney |first7=Ronald E |last8=Bharti |first8=Ajit |last9=Rodriguez |first9=Juan |last10=Feelisch |first10=Martin |title=Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues |journal=Nature Chemical Biology |date=October 2005 |volume=1 |issue=5 |pages=290–297 |doi=10.1038/nchembio734}}</ref><ref>{{cite journal |last1=Stamler |first1=J S |last2=Jaraki |first2=O |last3=Osborne |first3=J |last4=Simon |first4=D I |last5=Keaney |first5=J |last6=Vita |first6=J |last7=Singel |first7=D |last8=Valeri |first8=C R |last9=Loscalzo |first9=J |title=Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin. |journal=Proceedings of the National Academy of Sciences |date=15 August 1992 |volume=89 |issue=16 |pages=7674–7677 |doi=10.1073/pnas.89.16.7674}}</ref>. NO can be generated enzymatically or from NO reservoirs such as nitrite.<ref>{{cite book |title=Nitric oxide: biology and pathobiology |date=2017 |publisher=AP, Academic Press |location=London |isbn=9780128042731 |edition=Third}}</ref><ref>{{cite journal |last1=Gladwin |first1=Mark T. |last2=Raat |first2=Nicolaas J. H. |last3=Shiva |first3=Sruti |last4=Dezfulian |first4=Cameron |last5=Hogg |first5=Neil |last6=Kim-Shapiro |first6=Daniel B. |last7=Patel |first7=Rakesh P. |title=Nitrite as a vascular endocrine nitric oxide reservoir that contributes to hypoxic signaling, cytoprotection, and vasodilation |journal=American Journal of Physiology-Heart and Circulatory Physiology |date=November 2006 |volume=291 |issue=5 |pages=H2026–H2035 |doi=10.1152/ajpheart.00407.2006}}</ref>
== See also ==
* [[Autocrine signaling]] is a form of cell signaling in which a cell secretes a hormone or chemical messenger (called the autocrine agent) that binds to autocrine receptors on that same cell, leading to changes in the cell.
* [[Paracrine regulator|Paracrine signaling]] is a form of cell-cell communication in which a cell produces a signal to induce changes in nearby cells, altering the behavior or differentiation of nearby cells.
* [[Endocrine system]]
* [[Endocrinology]]
* [[Pancha Bhuta]], according to ayurveda and Yoga, are associated with overall health of human being. Any disorder in human body indicates imbalance of one or more of these elements.
== References ==
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