Phosphoinositide 3-kinase: Difference between revisions - Wikipedia

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===PI 3-kinases inhibitors as therapeutics===

{{Main|PI3K inhibitor}}

As [[wortmannin]] and [[LY294002]] are broad [[Phosphoinositide 3-kinase inhibitor|inhibitors against PI 3-kinases]] and a number of unrelated proteins at higher concentrations they are too toxic to be used as therapeutics.{{Citation needed|date=July 2010}} A number of pharmaceutical companies have recently been working on PI 3-kinase isoform specific inhibitors including the class I PI 3-kinase, [[p110δ]] isoform specific inhibitors, [[IC486068]] and [[IC87114]], [[ICOS Corporation]].{{Citation needed|date=August 2010}}.GDC-0941 is a highly selective inhibitor of p110α with little activity against mTOR.<ref name="Johannes Werzowa">Johannes Werzowa,Stefan Koehrer. [http://www.selleckchem.com/UploadFile/File/Papers/GDC-0941/IC87114-GDC-0941-201111.pdf GDC-0941] Vertical Inhibition of the mTORC1/mTORC2/PI3K Pathway Shows Synergistic Effects against Melanoma In Vitro and In Vivo. Selleck chemical LLC.</ref>

==References==