Shi Zhengli: Difference between revisions - Wikipedia
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Line 56: In 2014, Shi Zhengli collaborated on additional [[gain-of-function]] experiments led by [[Ralph S Baric]] of the [[University of North Carolina]], which showed that two critical mutations that the [[MERS]] coronavirus possesses allow it to bind to the human ACE2 receptor,<ref name="JV-20150610">{{cite journal |author=Yang, Yang |display-authors=et al. |title=Two Mutations Were Critical for Bat-to-Human Transmission of Middle East Respiratory Syndrome Coronavirus |date=10 June 2015 |journal=[[Journal of Virology]] |volume=89 |issue=17 |pages=9119–9123 |doi=10.1128/JVI.01279-15 |pmid=26063432 |pmc=4524054 }}</ref> and that SARS had the potential to re-emerge from coronaviruses circulating in bat populations in the wild.<ref>{{Cite journal|last1=Menachery|first1=Vineet D.|last2=Yount|first2=Boyd L.|last3=Debbink|first3=Kari|last4=Agnihothram|first4=Sudhakar|last5=Gralinski|first5=Lisa E.|last6=Plante|first6=Jessica A.|last7=Graham|first7=Rachel L.|last8=Scobey|first8=Trevor|last9=Ge|first9=Xing-Yi|last10=Donaldson|first10=Eric F.|last11=Randell|first11=Scott H.|date=11 November 2015|title=A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence|journal=Nature Medicine|volume=21|issue=12|pages=1508–1513|doi=10.1038/nm.3985|pmid=26552008|pmc=4797993|issn=1546-170X}}</ref> Shi and her colleague Cui Jie led a team which sampled thousands of [[horseshoe bat]]s throughout China. In 2017, they published their findings, indicating that all the genetic components of the [[SARS coronavirus]] existed in a bat population in [[Xiyang Yi Ethnic Township]], Yunnan.<ref name=":1"/> While no single bat harbored the exact strain of virus which caused the [[2002-2004 SARS outbreak]], genetic analysis showed that different strains often mix, suggesting that the human version likely emerged from a combination of the strains present in the bat population.<ref name=":1"/> Shi is the director of the Center for Emerging Infectious Diseases at the [[Wuhan Institute of Virology]] (WIV), located in [[Jiangxia District]], [[Wuhan]].<ref name="WIV-Director-Center">{{cite web |url=http://english.whiov.cas.cn/ne/201903/t20190308_206697.html |title=Prof. Shi Zhengli elected a fellow of the American Academy of Microbiology |date=8 March 2019 |access-date=31 December 2020 ===2020=== | |||