Skin: Difference between revisions - Wikipedia

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[[Keratinocytes]] in the [[stratum basale]] proliferate through [[mitosis]] and the daughter [[cell (biology)|cells]] move up the strata changing shape and composition as they undergo multiple stages of [[cell differentiation]] to eventually become anucleated. During that process, [[keratinocytes]] will become highly organized, forming [[cell junction|cellular junctions]] ([[desmosomes]]) between each other and secreting [[keratin]] [[proteins]] and [[lipids]] which contribute to the formation of an [[extracellular matrix]] and provide mechanical [[strength of materials|strength]] to the skin.<ref name="Pmid">{{cite journal | pmid=19333614 | year=2009 | last1=Breitkreutz | first1=D | last2=Mirancea | first2=N | last3=Nischt | first3=R | title=Basement membranes in skin: Unique matrix structures with diverse functions? | volume=132 | issue=1 | pages=1–10 | doi=10.1007/s00418-009-0586-0 | journal=Histochemistry and cell biology}}</ref> [[Keratinocytes]] from the [[stratum corneum]] are eventually shed from the surface ([[desquamation]]).

The [[epidermis (skin)|epidermis]] contains no [[blood vessel]]s, and [[cell (biology)|cells]] in the deepest layers are nourished by diffusion from [[blood]] [[capillaries]] extending to the upper layers of the [[dermis]].:,juyfhjtthhyjukjumimukiki

===Basement membrane===