Talk:Life extension: Difference between revisions - Wikipedia

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{{Outline of knowledge coverage|life extension}}

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== "Anti-aging hormore therapies" listed at [[Wikipedia:Redirects for discussion|Redirects for discussion]] ==

==Laron syndrome==

[[File:Information.svg|30px]]

Shouldn't we mention the [[Laron syndrome]] as a disease that could help us in creating life-extending therapies ? See http://www.nytimes.com/2011/02/17/science/17longevity.html?_r=0

An editor has identified a potential problem with the redirect [[:Anti-aging hormore therapies]] and has thus listed it [[Wikipedia:Redirects for discussion|for discussion]]. This discussion will occur at [[Wikipedia:Redirects for discussion/Log/2022 May 17#Anti-aging hormore therapies]] until a consensus is reached, and readers of this page are welcome to contribute to the discussion. <!-- from Template:RFDNote --> –[[User:LaundryPizza03|<b style="color:#77b">Laundry</b><b style="color:#fb0">Pizza</b><b style="color:#b00">03</b>]] ([[User talk:LaundryPizza03|<span style="color:#0d0">d</span>]][[Special:Contribs/LaundryPizza03|<span style="color:#0bf">c̄</span>]]) 09:40, 17 May 2022 (UTC)

==For users==

{{Longevist}}

Add { { Longevist} } to your user page.

== External links modified ==

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* [http://playersearch.win/pdfdata/pdf4.pdf 'The Science of Longevity' LONGEVITY INDUSTRY LANDSCAPE OVERVIEW 2017]. Volume I: The Science of Longevity.

Unfortunately, this link with valuable sources of information on the topic was deleted as a spam. Judge. Here's the content:

•Part I: Executive Summary........................................................................1

•Part II: Geroscience Research Landscape Overview 2017...................9

•Part III: Infographic Summary.................................................................65

•Part IV: '''Top 100 Longevity Research Labs'''.............................................76

•Part V: Top 100 Longevity Non-Profits................................................179

•Part VI: Top 100 Longevity Conferences.............................................281

•Part VII: '''Top 100 Longevity Journals'''...................................................383

•Part VIII: '''Top 100 Longevity Books'''......................................................484

== Article in Nautilus ==

•Part IX: '''Top 100 Geroscientists'''............................................................589

I thought this article might be of interest. It discusses the effectiveness of things like [[nicotinamide adenine dinucleotide]] (NAD), [[nicotinamide mononucleotide]] (NMN), [[nicotinamide riboside]] (NR), [[sirtuins]], & [[resveratrol]], as well as controversies surrounding the research, researchers, & commercialization.

•Part X: '''Top 50 Longevity Databases'''....................................................701

*{{cite web |last=Fuchs |first=Matt |title=The Longevity Skeptic |website=Nautilus |date=2023-05-23 |url=https://nautil.us/the-longevity-skeptic-305806/ |access-date=2023-05-25 |ref=none}}

Regarding longevity or life extension researchers, this may be something for which we need a category. [[User:Peaceray|Peaceray]] ([[User talk:Peaceray|talk]]) 16:10, 25 May 2023 (UTC)

:It's not a [[WP:RS]] source, so is unusable, but rather is a summary of opinions based on lab research. [[Sirtuin]]s, [[resveratrol]], and NAD supplementation have no support for efficacy in [[randomized controlled trial]]s or any [[WP:MEDASSESS]] sources.

[[User:Dmitry Dzhagarov|Dmitry Dzhagarov]] ([[User talk:Dmitry Dzhagarov|talk]]) 07:08, 8 February 2018 (UTC)

:[https://www.chromadex.com/tru-niagen/ Here's the ChromaDex website] where Brenner is presented and effects of the product, ''TRU Niagen'', are falsely presented as having benefit in humans, something that has never been proven in vivo (if it did, it would be classified and [[drug approval|approved as a prescription drug]] by the FDA).

::How is it a reliable source? [[User:Doc James|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Doc James|talk]] · [[Special:Contributions/Doc James|contribs]] · [[Special:EmailUser/Doc James|email]]) 09:52, 8 February 2018 (UTC)

:As a supplement, TRU Niagen brings in [https://investors.chromadex.com/news/news-details/2023/ChromaDex-Corporation-Reports-First-Quarter-2023-Financial-Results/default.aspx $17.6 million per quarter] or 78% of total ChromaDex revenues, possibly revealing Brenner's true motivation for being affiliated with a supplement company, if he's getting a decent cut. That product income of about $70 million per year is being earned at the expense of a deceived public.

:This presentation of Brenner as a "longevity skeptic" is quite comical, duplicitous, and hypocritical. He has solid academic credentials from a career in lab research, then joins a supplement company with a product (consistent with his research) having no basis for in vivo benefit in humans. What Sinclair, Brenner and other advocates of taking supplements with supposed anti-disease or anti-aging benefits seem to conveniently ignore is that an orally-consumed product - as for any food complex - is subjected to the acidic and enzymatic environment of the stomach, which would dissolve and break apart molecules, leaving only individual derivatives to circulate in the blood with unknown concentrations, tissue targets, or cellular properties. [[User:Zefr|Zefr]] ([[User talk:Zefr|talk]]) 17:12, 25 May 2023 (UTC)

::Hi, perhaps I should have been clear I was not suggesting its use for the article. BTW, there is nothing about Nautilus either way at [[WP:RS/P]], so I take issue with automatically branding it as non-WP:RS. That said, it is clear that the ''only'' sources that should be used for articles like this is articles that meet [[WP:MEDRS]], which this source is decidedly ''not''. It might well be suitable for citing Brunner's opinions in [[Charles Brenner (biochemist)|the article about him]].

::My main purpose in posting the citation was to stimulate discussion amongst other editors, something I often do to talk pages, especially since it cites primary studies (again, themselves not suitable for citation as WP:MEDRS requires secondary & tertiary sources, but perhaps of interest). It has elicited comment! Thank you Zefr for your critique. [[User:Peaceray|Peaceray]] ([[User talk:Peaceray|talk]]) 19:43, 25 May 2023 (UTC)

::Also, while I think any medical consensus is further down the road, here is a review of the literature concerning the oral administration of NAD+ boosting compounds.

::*{{cite journal |last=Freeberg |first=Kaitlin A |last2=Udovich |first2=Ce Ann C |last3=Martens |first3=Christopher R |last4=Seals |first4=Douglas R |last5=Craighead |first5=Daniel H |title=Dietary Supplementation With NAD+-Boosting Compounds in Humans: Current Knowledge and Future Directions |journal=The Journals of Gerontology: Series A |publisher=Oxford University Press (OUP) |date=2023-04-17 |issn=1079-5006 |doi=10.1093/gerona/glad106 |ref=none}}

::{{clear}} [[User:Peaceray|Peaceray]] ([[User talk:Peaceray|talk]]) 19:50, 25 May 2023 (UTC)