In microbiology and medicine, the GmPcides are a family of compounds that are highly effective at fighting a broad range of Gram-positive bacteria, including Streptococcus pyogenes, one of the organisms that can cause necrotizing fasciitis in humans.[1]
Several GmPcides have been found to be active in vitro against Enterococcus faecalis, which is naturally highly resistant to antibiotics.[2] The same study also found one of them to greatly enhance the effectiveness of such conventional antibiotics as gentamicin and vancomycin against E. Faecalis.
The effectiveness of a GmPcide at treating infections by such organisms as S. pyogenes (commonly referred to as flesh-eating bacteria) in vivo was first reported in a 2024 study in mice.[3]
- ^ "New compound found to be effective against 'flesh-eating' bacteria". phys.org. August 2, 2024. Retrieved August 5, 2024.
- ^ Nye, Taylor M.; Tükenmez, Hasan; Singh, Pardeep; Huntgren, Scott J. (October 17, 2022). "Ring-fused 2-pyridones effective against multidrug-resistant Gram-positive pathogens and synergistic with standard-of-care antibiotics". Proc. Nat. Acad. Sci. 119 (43): e2210912119. Bibcode:2022PNAS..11910912N. doi:10.1073/pnas.2210912119. PMC 9618150. PMID 36252016.
- ^ Zou, Zongsen; et al. (August 2, 2024). "Dihydrothiazolo ring-fused 2-pyridone antimicrobial compounds treat Streptococcus pyogenes skin and soft tissue infection". Science Advances. 10 (31): eadn7979. Bibcode:2024SciA...10N7979Z. doi:10.1126/sciadv.adn7979. PMC 11296344. PMID 39093975.