Supreme Commander may refer to:
- Commander-in-chief, a military rank
- Generalissimo or generalissimus, a (usually informal) term for a senior military commander, or a foreign term for a senior general
- Allied Supreme Commander, position held by Marshal Ferdinand Foch during World War I
- Supreme Allied Commander, title held by the most senior commander within certain multinational military alliances
- Supreme Allied Commander Europe, military commander of the North Atlantic Treaty Organization (NATO)
- Supreme Allied Commander Atlantic, head of NATO's now-defunct Allied Command Atlantic
- Supreme Commander for the Allied Powers, title held by General Douglas MacArthur during the Occupation of Japan following World War II
- Supreme Commander of the People's Republic of China
- Supreme Commander of the Armed Forces of North Korea
- Supreme Commander of the Malaysian Armed Forces
- Supreme Commander-in-Chief of the Armed Forces of the Russian Federation
- Supreme Commander of the Swedish Armed Forces
- Supreme Commander of the Unified Armed Forces of the Warsaw Treaty Organization
- Supreme commander (militant), a title used for the head of a militant group or an organization
- Supreme Commander video game series developed by Gas Powered Games
- Supreme Commander (video game), real-time strategy video game released in 2007
- Supreme Commander: Forged Alliance, a stand-alone expansion for Supreme Commander released in 2007
- Supreme Commander 2, the sequel to Supreme Commander released in 2010