Comparison of ceftriaxone with cefotaxime in serious chest infections - PubMed
J H Reeves 1 , G M Russell, J F Cade, M McDonald
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Comparison of ceftriaxone with cefotaxime in serious chest infections
J H Reeves et al. Chest. 1989 Dec.
Abstract
Ceftriaxone is a new, third-generation cephalosporin that, because of its long half-life, offers potential advantages of cost and convenience over similar agents such as cefotaxime. We compared the two drugs in a prospective, randomized study of the treatment of chest infections in seriously ill patients. Fifty-one patients (90 percent of whom were mechanically ventilated) received either ceftriaxone, 2g IV once daily, or cefotaxime, 2 g IV thrice daily, for five days. The two groups of patients appeared demographically comparable. Ceftriaxone in a single daily dose of 2 g once daily may not be satisfactory for the treatment of serious chest infections.
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