Pyronaridine


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Pyronaridine is an antimalarial drug. It was first synthesized in 1970 and has been in clinical use in China since the 1980s. It was first assayed by Adegoke and Babalola in 2006.[1]

Pyronaridine
Clinical data
Routes of
administration		Oral, intramuscular injection, intravenous therapy
ATC code
  • none
Legal status
Legal status
  • CLP (EU): Acute Tox. 3(H301), Eye Dam. 1 (H318), Repr. 2 (H361), Aquatic Chronic 4 (H413)
Identifiers

  • 4-[(7-chloro-2-methoxy-pyrido[3,2-b]quinolin-10-yl)amino]-2,6-bis(pyrrolidin-1-ylmethyl)phenol

CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC29H32ClN5O2
Molar mass518.05 g/mol g·mol−1
3D model (JSmol)

  • Clc1ccc6c(c1)nc2ccc(OC)nc2c6Nc5cc(CN3CCCC3)c(O)c(CN4CCCC4)c5

  • InChI=1S/C29H32ClN5O2/c1-37-26-9-8-24-28(33-26)27(23-7-6-21(30)16-25(23)32-24)31-22-14-19(17-34-10-2-3-11-34)29(36)20(15-22)18-35-12-4-5-13-35/h6-9,14-16,36H,2-5,10-13,17-18H2,1H3,(H,31,32) check

  • Key:DJUFPMUQJKWIJB-UHFFFAOYSA-N check

 ☒check (what is this?)  (verify)

It is one of the components of Pyramax.

References

  1. ^ Chang C, Lin-Hua T, Jantanavivat C (1992). "Studies on a new antimalarial compound: pyronaridine". Trans R Soc Trop Med Hyg. 86 (1): 7–10. doi:10.1016/0035-9203(92)90414-8. PMID 1566313.{{cite journal}}: CS1 maint: multiple names: authors list (link)

Adegoke & Babalola 2006