ABCC10

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Multidrug resistance-associated protein 7 is a protein that in humans is encoded by the ABCC10 gene.^[5]^[6]

ABCC10

Identifiers

Aliases

ABCC10, EST182763, MRP7, SIMRP7, ATP binding cassette subfamily C member 10

External IDs

OMIM: 612509; MGI: 2386976; HomoloGene: 58616; GeneCards: ABCC10; OMA:ABCC10 - orthologs

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	6p21.1	Start	43,427,366 bp^[1]
Band	6p21.1	End	43,450,427 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)^[2]

Band	17\|17 C	Start	46,614,147 bp^[2]
Band	17\|17 C	End	46,639,278 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right hemisphere of cerebellum

granulocyte

right ovary

pituitary gland

anterior pituitary

right adrenal cortex

apex of heart

left ovary

epithelium of nasopharynx

right frontal lobe

Top expressed in

substantia nigra

trigeminal ganglion

yolk sac

spermatocyte

neural layer of retina

right kidney

duodenum

proximal tubule

ascending aorta

secondary oocyte

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nucleotide binding ATPase activity ATP binding ATPase-coupled inorganic anion transmembrane transporter activity ATPase-coupled transmembrane transporter activity
Cellular component	integral component of membrane lysosomal membrane plasma membrane membrane integral component of plasma membrane
Biological process	transmembrane transport transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


89845


224814

Ensembl


ENSG00000124574


ENSMUSG00000032842

UniProt


Q5T3U5


Q8R4P9

RefSeq (mRNA)


NM_001198934 NM_033450 NM_001350518


NM_145140 NM_170680 NM_001347396

RefSeq (protein)


NP_001185863 NP_258261 NP_001337447


NP_001334325 NP_660122 NP_733780

Location (UCSC)

Chr 6: 43.43 – 43.45 Mb

Chr 17: 46.61 – 46.64 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described.^[6]

ATP-binding cassette transporter

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124574 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032842 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Allikmets R, Gerrard B, Hutchinson A, Dean M (Feb 1997). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Hum Mol Genet. 5 (10): 1649–55. doi:10.1093/hmg/5.10.1649. PMID 8894702.
^ ^a ^b "Entrez Gene: ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10".

Hopper E, Belinsky MG, Zeng H, et al. (2001). "Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily". Cancer Lett. 162 (2): 181–91. doi:10.1016/S0304-3835(00)00646-7. PMID 11146224.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chen ZS, Hopper-Borge E, Belinsky MG, et al. (2003). "Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10)". Mol. Pharmacol. 63 (2): 351–8. doi:10.1124/mol.63.2.351. PMID 12527806. S2CID 26642179.
Kao HH, Chang MS, Cheng JF, Huang JD (2003). "Genomic structure, gene expression, and promoter analysis of human multidrug resistance-associated protein 7". J. Biomed. Sci. 10 (1): 98–110. doi:10.1159/000068078. PMID 12566991. S2CID 202649323.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404. S2CID 4423608.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. S2CID 21903526.
Hopper-Borge E, Chen ZS, Shchaveleva I, et al. (2004). "Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): resistance to docetaxel". Cancer Res. 64 (14): 4927–30. doi:10.1158/0008-5472.CAN-03-3111. PMID 15256465. S2CID 6933602.
Wooden SL, Kalb SR, Cotter RJ, Soloski MJ (2005). "Cutting edge: HLA-E binds a peptide derived from the ATP-binding cassette transporter multidrug resistance-associated protein 7 and inhibits NK cell-mediated lysis". J. Immunol. 175 (3): 1383–7. doi:10.4049/jimmunol.175.3.1383. PMID 16034073. S2CID 22554947.
Naramoto H, Uematsu T, Uchihashi T, et al. (2007). "Multidrug resistance-associated protein 7 expression is involved in cross-resistance to docetaxel in salivary gland adenocarcinoma cell lines". Int. J. Oncol. 30 (2): 393–401. doi:10.3892/ijo.30.2.393 (inactive 2024-09-13). PMID 17203221.{{cite journal}}: CS1 maint: DOI inactive as of September 2024 (link)

ABCC10+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human ABCC10 genome location and ABCC10 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.