Annexin A3

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Annexin A3 is a protein that in humans is encoded by the ANXA3 gene.^[5]^[6]

ANXA3

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1AII, 1AXN

Identifiers

Aliases

ANXA3, ANX3, annexin A3

External IDs

OMIM: 106490; MGI: 1201378; HomoloGene: 68445; GeneCards: ANXA3; OMA:ANXA3 - orthologs

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4q21.21	Start	78,551,747 bp^[1]
Band	4q21.21	End	78,610,451 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5 E3\|5 47.29 cM	Start	96,941,198 bp^[2]
Band	5 E3\|5 47.29 cM	End	96,993,825 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right lung

germinal epithelium

bone marrow

upper lobe of left lung

bone marrow cells

minor salivary glands

left lobe of thyroid gland

trabecular bone

right lobe of thyroid gland

body of stomach

Top expressed in

right lung lobe

mucous cell of stomach

pyloric antrum

endothelial cell of lymphatic vessel

left lung

granulocyte

left lung lobe

decidua

epithelium of stomach

gastrula

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	phospholipase inhibitor activity calcium ion binding phospholipase A2 inhibitor activity calcium-dependent protein binding calcium-dependent phospholipid binding
Cellular component	cytoplasm phagocytic vesicle membrane membrane plasma membrane axon neuronal cell body dendrite specific granule extracellular exosome cytosol
Biological process	negative regulation of catalytic activity positive regulation of DNA metabolic process neutrophil degranulation positive regulation of DNA-binding transcription factor activity response to glucocorticoid positive regulation of angiogenesis positive regulation of endothelial cell migration defense response to bacterium animal organ regeneration phagocytosis response to growth factor hippocampus development homophilic cell adhesion via plasma membrane adhesion molecules regulation of NMDA receptor activity
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


306


11745

Ensembl


ENSG00000138772


ENSMUSG00000029484

UniProt


P12429


O35639

RefSeq (mRNA)


NM_005139


NM_013470

RefSeq (protein)


NP_005130


NP_038498

Location (UCSC)

Chr 4: 78.55 – 78.61 Mb

Chr 5: 96.94 – 96.99 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

It is abnormally expressed in fetuses of both IVF and ICSI, which may contribute to the increase risk of birth defects in these ART.^[7]

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phospholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138772 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029484 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tait JF, Frankenberry DA, Miao CH, Killary AM, Adler DA, Disteche CM (Aug 1991). "Chromosomal localization of the human annexin III (ANX3) gene". Genomics. 10 (2): 441–8. doi:10.1016/0888-7543(91)90330-H. PMID 1830024.
^ ^a ^b "Entrez Gene: ANXA3 annexin A3".
^ Zhang Y, Zhang YL, Feng C, et al. (September 2008). "Comparative proteomic analysis of human placenta derived from assisted reproductive technology". Proteomics. 8 (20): 4344–56. doi:10.1002/pmic.200800294. PMID 18792929. S2CID 206362532.

Human ANXA3 genome location and ANXA3 gene details page in the UCSC Genome Browser.

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