ASAH2

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Neutral ceramidase is an enzyme that in humans is encoded by the ASAH2 gene.^[5]^[6]

ASAH2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4WGK

Identifiers

Aliases

ASAH2, BCDase, HNAC1, LCDase, N-CDase, NCDase, N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2, N-acylsphingosine amidohydrolase 2

External IDs

OMIM: 611202; MGI: 1859310; HomoloGene: 10310; GeneCards: ASAH2; OMA:ASAH2 - orthologs

Gene location (Human)

Chr.	Chromosome 10 (human)^[1]

Band	10q11.23	Start	50,182,778 bp^[1]
Band	10q11.23	End	50,279,720 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)^[2]

Band	19\|19 C1	Start	31,959,997 bp^[2]
Band	19\|19 C1	End	32,085,611 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

duodenum

gonad

testicle

stromal cell of endometrium

islet of Langerhans

smooth muscle tissue

ganglionic eminence

muscle of thigh

tonsil

skeletal muscle tissue

Top expressed in

epithelium of small intestine

intestinal villus

jejunum

lacrimal gland

duodenum

esophagus

parotid gland

Epithelium of choroid plexus

deep cerebellar nuclei

motor neuron

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	hydrolase activity ceramidase activity calcium ion binding zinc ion binding N-acylsphingosine amidohydrolase activity metal ion binding
Cellular component	integral component of membrane plasma membrane membrane mitochondrion extracellular region
Biological process	lipid metabolism sphingolipid metabolic process apoptotic process sphingosine metabolic process ceramide metabolic process response to organic substance long-chain fatty acid biosynthetic process sphingosine biosynthetic process ceramide catabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


56624


54447

Ensembl


ENSG00000188611


ENSMUSG00000024887

UniProt


Q9NR71


Q9JHE3

RefSeq (mRNA)


NM_001143974 NM_019893


NM_018830

RefSeq (protein)


NP_001137446 NP_063946


NP_061300

Location (UCSC)

Chr 10: 50.18 – 50.28 Mb

Chr 19: 31.96 – 32.09 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000188611 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024887 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ El Bawab S, Roddy P, Qian T, Bielawska A, Lemasters JJ, Hannun YA (Aug 2000). "Molecular cloning and characterization of a human mitochondrial ceramidase". J Biol Chem. 275 (28): 21508–13. doi:10.1074/jbc.M002522200. PMID 10781606.
^ "Entrez Gene: ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2".

Human ASAH2 genome location and ASAH2 gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: Q9NR71 (Neutral ceramidase; ASAH2) at the PDBe-KB.

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Tani M, Okino N, Mori K, et al. (2000). "Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases". J. Biol. Chem. 275 (15): 11229–34. doi:10.1074/jbc.275.15.11229. PMID 10753931.
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Ohlsson L, Palmberg C, Duan RD, et al. (2007). "Purification and characterization of human intestinal neutral ceramidase". Biochimie. 89 (8): 950–60. doi:10.1016/j.biochi.2007.03.009. PMID 17475390.