ATP6V0C

V-type proton ATPase 16 kDa proteolipid subunit is an enzyme that in humans is encoded by the ATP6V0C gene.^[5][6][7]

ATP6V0C
Identifiers
Aliases	ATP6V0C, ATP6C, ATP6L, ATPL, VATL, VPPC, Vma3, ATPase H+ transporting V0 subunit c
External IDs	OMIM: 108745; MGI: 88116; HomoloGene: 68199; GeneCards: ATP6V0C; OMA:ATP6V0C - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 2,513,952 bp[1] End 2,520,218 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A3.3 Start 24,163,866 bp[2] End 24,169,702 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in superior frontal gyrus right frontal lobe right hemisphere of cerebellum primary visual cortex prefrontal cortex Brodmann area 9 anterior cingulate cortex anterior pituitary hypothalamus nucleus accumbens Top expressed in hippocampus proper primary visual cortex dentate gyrus of hippocampal formation granule cell superior frontal gyrus olfactory bulb hypothalamus cerebellar cortex basal forebrain striatum of neuraxis right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function proton-transporting ATP synthase activity, rotational mechanism proton-transporting ATPase activity, rotational mechanism protein binding proton transmembrane transporter activity ubiquitin protein ligase binding Cellular component proton-transporting V-type ATPase, V0 domain phagocytic vesicle membrane proton-transporting two-sector ATPase complex, proton-transporting domain membrane vacuolar membrane focal adhesion vacuolar proton-transporting V-type ATPase, V0 domain lysosomal membrane vacuole endosome membrane extracellular exosome plasma membrane azurophil granule membrane tertiary granule membrane ficolin-1-rich granule membrane integral component of membrane Biological process insulin receptor signaling pathway lysosomal lumen acidification transferrin transport ion transport positive regulation of Wnt signaling pathway ion transmembrane transport viral process regulation of macroautophagy phagosome acidification neutrophil degranulation transport proton transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 527 11984 Ensembl ENSG00000185883 ENSMUSG00000024121 UniProt P27449 P63082 RefSeq (mRNA) NM_001694 NM_001198569 NM_009729 RefSeq (protein) NP_001185498 NP_001685 NP_033859 NP_001348460 NP_001348461 NP_001348462 NP_001348463 NP_001348464 Location (UCSC) Chr 16: 2.51 – 2.52 Mb Chr 17: 24.16 – 24.17 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is part of the V0 domain. This gene had the previous symbols of ATP6C and ATP6L.^[7]

• Human ATP6V0C genome location and ATP6V0C gene details page in the UCSC Genome Browser.