CEP350

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Centrosome-associated protein 350 is a protein that in humans is encoded by the CEP350 gene.^[5]^[6]^[7]

CEP350

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2COZ

Identifiers

Aliases

CEP350, CAP350, GM133, centrosomal protein 350

External IDs

OMIM: 617870; MGI: 1921331; HomoloGene: 8879; GeneCards: CEP350; OMA:CEP350 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1q25.2	Start	179,954,773 bp^[1]
Band	1q25.2	End	180,114,875 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)^[2]

Band	1\|1 G3	Start	155,720,710 bp^[2]
Band	1\|1 G3	End	155,849,001 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

sperm

trabecular bone

nipple

left testis

Achilles tendon

right testis

optic nerve

pancreatic ductal cell

jejunal mucosa

gingival epithelium

Top expressed in

medullary collecting duct

epithelium of stomach

ciliary body

pyloric antrum

retinal pigment epithelium

triceps brachii muscle

vastus lateralis muscle

Epithelium of choroid plexus

temporal muscle

mucous cell of stomach

More reference expression data

BioGPS

More reference expression data

Gene ontology
Molecular function	microtubule binding protein binding
Cellular component	centrosome spindle cytoskeleton membrane nucleus microtubule organizing center cytoplasm cell projection centriole
Biological process	microtubule anchoring
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9857


74081

Ensembl


ENSG00000135837


ENSMUSG00000033671

UniProt


Q5VT06


E9Q309

RefSeq (mRNA)


NM_014810


NM_001039184

RefSeq (protein)


NP_055625


NP_001034273

Location (UCSC)

Chr 1: 179.95 – 180.11 Mb

Chr 1: 155.72 – 155.85 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

CEP350 is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. It primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. CEP350 is required to anchor microtubules at the centrosome. Furthermore, it increases the stability of growing centrioles.^[8]

It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135837 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033671 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yan X, Habedanck R, Nigg EA (Jan 2006). "A Complex of Two Centrosomal Proteins, CAP350 and FOP, Cooperates with EB1 in Microtubule Anchoring". Mol Biol Cell. 17 (2): 634–44. doi:10.1091/mbc.E05-08-0810. PMC 1356575. PMID 16314388.
^ Patel H, Truant R, Rachubinski RA, Capone JP (Dec 2004). "Activity and subcellular compartmentalization of peroxisome proliferator-activated receptor alpha are altered by the centrosome-associated protein CAP350". J Cell Sci. 118 (Pt 1): 175–86. doi:10.1242/jcs.01600. PMID 15615782.
^ ^a ^b "Entrez Gene: CEP350 centrosomal protein 350kDa".
^ Le Clech, M (2008). "Role of CAP350 in centriolar tubule stability and centriole assembly". PLOS ONE. 3 (12): e3855. Bibcode:2008PLoSO...3.3855L. doi:10.1371/journal.pone.0003855. PMC 2586089. PMID 19052644.

Human CEP350 genome location and CEP350 gene details page in the UCSC Genome Browser.

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