Centrin 1

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Centrin-1 is a protein that in humans is encoded by the CETN1 gene.^[5]^[6] It belongs to the centrin family of proteins.

CETN1

Identifiers

Aliases

CETN1, CEN1, CETN, centrin 1

External IDs

OMIM: 603187; MGI: 1347086; HomoloGene: 105668; GeneCards: CETN1; OMA:CETN1 - orthologs

Gene location (Human)

Chr.	Chromosome 18 (human)^[1]

Band	18p11.32	Start	580,380 bp^[1]
Band	18p11.32	End	582,114 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 18 (mouse)^[2]

Band	18\|18 A1	Start	9,615,524 bp^[2]
Band	18\|18 A1	End	9,619,478 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

left testis

right testis

sperm

testicle

human musculoskeletal system

muscular system

muscle

muscle

skeletal muscle

muscle of lower limb

Top expressed in

spermatid

spermatocyte

seminiferous tubule

lumbar subsegment of spinal cord

motor neuron

tibiofemoral joint

submandibular gland

spinal ganglia

carotid body

trachea

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	microtubule binding calcium ion binding G-protein beta/gamma-subunit complex binding heterotrimeric G-protein binding protein binding metal ion binding
Cellular component	cytoplasm microtubule organizing center centrosome spindle pole cytoskeleton photoreceptor connecting cilium centriole nucleus
Biological process	cell cycle cellular response to heat cell division mitotic cytokinesis centriole replication regulation of centrosome duplication calcium-mediated signaling regulation of cytokinesis microtubule cytoskeleton organization nucleotide-excision repair mitotic cell cycle
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


1068


26369

Ensembl


ENSG00000177143


ENSMUSG00000050996

UniProt


Q12798


P41209

RefSeq (mRNA)


NM_004066


NM_007593

RefSeq (protein)


NP_004057


NP_031619

Location (UCSC)

Chr 18: 0.58 – 0.58 Mb

Chr 18: 9.62 – 9.62 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This encoded protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000177143 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050996 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Errabolu R, Sanders MA, Salisbury JL (Jun 1994). "Cloning of a cDNA encoding human centrin, an EF-hand protein of centrosomes and mitotic spindle poles". J Cell Sci. 107. ( Pt 1): 9–16. doi:10.1242/jcs.107.1.9. PMID 8175926.
^ ^a ^b "Entrez Gene: CETN1 centrin, EF-hand protein, 1".

Human CETN1 genome location and CETN1 gene details page in the UCSC Genome Browser.

Tsang WY, Spektor A, Luciano DJ, et al. (2006). "CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability". Mol. Biol. Cell. 17 (8): 3423–34. doi:10.1091/mbc.E06-04-0371. PMC 1525247. PMID 16760425.
Zhao ZS, Lim JP, Ng YW, et al. (2006). "The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A". Mol. Cell. 20 (2): 237–49. doi:10.1016/j.molcel.2005.08.035. hdl:10536/DRO/DU:30131061. PMID 16246726.
Poole E, Strappe P, Mok HP, et al. (2005). "HIV-1 Gag-RNA interaction occurs at a perinuclear/centrosomal site; analysis by confocal microscopy and FRET". Traffic. 6 (9): 741–55. doi:10.1111/j.1600-0854.2005.00312.x. PMID 16101678. S2CID 36574274.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lutz W, Lingle WL, McCormick D, et al. (2001). "Phosphorylation of centrin during the cell cycle and its role in centriole separation preceding centrosome duplication". J. Biol. Chem. 276 (23): 20774–80. doi:10.1074/jbc.M101324200. PMID 11279195.
Laoukili J, Perret E, Middendorp S, et al. (2000). "Differential expression and cellular distribution of centrin isoforms during human ciliated cell differentiation in vitro". J. Cell Sci. 113. ( Pt 8) (8): 1355–64. doi:10.1242/jcs.113.8.1355. PMID 10725219.