Calmegin


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Calmegin, also known as CLGN, is a protein which in humans is encoded by the CLGN gene.[5] Calmegin is also present in other animals including mice.[6]

CLGN
Identifiers
AliasesCLGN, calmegin
External IDsOMIM: 601858; MGI: 107472; HomoloGene: 68392; GeneCards: CLGN; OMA:CLGN - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]

Chromosome 4 (human)

Genomic location for CLGN

Genomic location for CLGN

Band4q31.1Start140,388,453 bp[1]
End140,427,661 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]

Chromosome 8 (mouse)

Genomic location for CLGN

Genomic location for CLGN

Band8 C2|8 39.97 cMStart84,116,496 bp[2]
End84,155,181 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right ventricle

  • myocardium of left ventricle

  • left testis

  • right testis

  • cardiac muscle tissue of right atrium

  • right auricle

  • endothelial cell

  • islet of Langerhans

  • apex of heart

  • retinal pigment epithelium
Top expressed in
  • spermatocyte

  • spermatid

  • seminiferous tubule

  • olfactory epithelium

  • lumbar spinal ganglion

  • trigeminal ganglion

  • facial motor nucleus

  • anterior horn of spinal cord

  • medulla oblongata

  • substantia nigra
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1047

12745

Ensembl

ENSG00000153132

ENSMUSG00000002190

UniProt

O14967

P52194

RefSeq (mRNA)

NM_001130675
NM_004362

NM_009904
NM_001329627
NM_001329680

RefSeq (protein)

NP_001124147
NP_004353

NP_001316556
NP_001316609
NP_034034

Location (UCSC)Chr 4: 140.39 – 140.43 MbChr 8: 84.12 – 84.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calmegin is a testis-specific endoplasmic reticulum chaperone protein. CLGN may play a role in spermatogeneisis and infertility.[5]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000153132Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002190Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: CLGN calmegin".
  6. ^ Watanabe D, Yamada K, Nishina Y, Tajima Y, Koshimizu U, Nagata A, Nishimune Y (March 1994). "Molecular cloning of a novel Ca(2+)-binding protein (calmegin) specifically expressed during male meiotic germ cell development". J. Biol. Chem. 269 (10): 7744–7749. doi:10.1016/S0021-9258(17)37349-0. PMID 8126001.