Collectin-12

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Collectin-12, also known as collectin subfamily member 12, is a collectin protein that in humans is encoded by the COLEC12 gene.^[5]

COLEC12

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2OX8

Identifiers

Aliases

COLEC12, CLP1, NSR2, SCARA4, SRCL, collectin subfamily member 12

External IDs

OMIM: 607621; MGI: 2152907; HomoloGene: 34248; GeneCards: COLEC12; OMA:COLEC12 - orthologs

Gene location (Human)

Chr.	Chromosome 18 (human)^[1]

Band	18p11.32	Start	316,737 bp^[1]
Band	18p11.32	End	500,722 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 18 (mouse)^[2]

Band	18\|18 A1	Start	9,707,595 bp^[2]
Band	18\|18 A1	End	9,882,644 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

synovial joint

tibia

synovial membrane

tendon of biceps brachii

retinal pigment epithelium

placenta

skin of hip

periodontal fiber

pericardium

cartilage tissue

Top expressed in

basilar part of occipital bone

mesothelium of peritoneum

sphenoid bone

calvaria

basisphenoid

pericardium

vestibular sensory epithelium

external carotid artery

pleura

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	pattern recognition receptor activity galactose binding metal ion binding low-density lipoprotein particle binding scavenger receptor activity carbohydrate binding
Cellular component	integral component of membrane endocytic vesicle membrane collagen membrane plasma membrane extracellular space extracellular matrix
Biological process	defense response positive regulation of cell adhesion molecule production carbohydrate mediated signaling receptor-mediated endocytosis immune response cellular response to exogenous dsRNA phagocytosis, recognition innate immune response toll-like receptor 3 signaling pathway protein homooligomerization regulation of immune response
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


81035


140792

Ensembl


ENSG00000158270


ENSMUSG00000036103

UniProt


Q5KU26


Q8K4Q8

RefSeq (mRNA)


NM_030781 NM_130386


NM_130449

RefSeq (protein)


NP_569057


NP_569716

Location (UCSC)

Chr 18: 0.32 – 0.5 Mb

Chr 18: 9.71 – 9.88 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

This gene encodes a member of the collectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor that displays several functions associated with host defense. It can bind to carbohydrate antigens on microorganisms, facilitating their recognition and removal. It also mediates the recognition, internalization, and degradation of oxidatively modified low density lipoprotein by vascular endothelial cells. [provided by RefSeq, May 2018].

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000158270 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036103 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Collectin subfamily member 12". Retrieved 2019-12-24.

Ohmori H, Makita Y, Funamizu M, Chiba S, Ohtani K, Suzuki Y, Wakamiya N, Hata A (2003). "Haplotype analysis of the human collectin placenta 1 (hCL-P1) gene". J. Hum. Genet. 48 (2): 82–5. doi:10.1007/s100380300011. PMID 12601552.
Yoshida T, Tsuruta Y, Iwasaki M, Yamane S, Ochi T, Suzuki R (March 2003). "SRCL/CL-P1 recognizes GalNAc and a carcinoma-associated antigen, Tn antigen". J. Biochem. 133 (3): 271–7. doi:10.1093/jb/mvg037. PMID 12761161.
Coombs PJ, Graham SA, Drickamer K, Taylor ME (June 2005). "Selective binding of the scavenger receptor C-type lectin to Lewisx trisaccharide and related glycan ligands". J. Biol. Chem. 280 (24): 22993–9. doi:10.1074/jbc.M504197200. hdl:11858/00-001M-0000-0011-5639-F. PMID 15845541.
Selman L, Skjodt K, Nielsen O, Floridon C, Holmskov U, Hansen S (June 2008). "Expression and tissue localization of collectin placenta 1 (CL-P1, SRCL) in human tissues". Mol. Immunol. 45 (11): 3278–88. doi:10.1016/j.molimm.2008.02.018. PMID 18423602.
Jang S, Ohtani K, Fukuoh A, Yoshizaki T, Fukuda M, Motomura W, Mori K, Fukuzawa J, Kitamoto N, Yoshida I, Suzuki Y, Wakamiya N (February 2009). "Scavenger receptor collectin placenta 1 (CL-P1) predominantly mediates zymosan phagocytosis by human vascular endothelial cells". J. Biol. Chem. 284 (6): 3956–65. doi:10.1074/jbc.M807477200. PMID 19073604.
Samsen A, Bogoevska V, Klampe B, Bamberger AM, Lucka L, Horst AK, Nollau P, Wagener C (January 2010). "DC-SIGN and SRCL bind glycans of carcinoembryonic antigen (CEA) and CEA-related cell adhesion molecule 1 (CEACAM1): recombinant human glycan-binding receptors as analytical tools". Eur. J. Cell Biol. 89 (1): 87–94. doi:10.1016/j.ejcb.2009.11.018. PMID 20034698.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M (April 2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Graham SA, Antonopoulos A, Hitchen PG, Haslam SM, Dell A, Drickamer K, Taylor ME (July 2011). "Identification of neutrophil granule glycoproteins as Lewis(x)-containing ligands cleared by the scavenger receptor C-type lectin". J. Biol. Chem. 286 (27): 24336–49. doi:10.1074/jbc.M111.244772. PMC 3129213. PMID 21561871.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.