CSN3 (gene)

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Kappa-casein is a protein that in humans is encoded by the CSN3 gene.^[5]^[6]^[7]

CSN3

Identifiers

Aliases

CSN3, CSN10, CSNK, KCA, CNS10, casein kappa

External IDs

OMIM: 601695; MGI: 107461; HomoloGene: 3818; GeneCards: CSN3; OMA:CSN3 - orthologs

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4q13.3	Start	70,238,382 bp^[1]
Band	4q13.3	End	70,251,474 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5 E1\|5 43.56 cM	Start	88,073,438 bp^[2]
Band	5 E1\|5 43.56 cM	End	88,080,524 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

buccal mucosa cell

minor salivary glands

olfactory zone of nasal mucosa

tonsil

epithelium of lactiferous gland

gonad

lactiferous duct

lymph node

islet of Langerhans

uterine tube

Top expressed in

lactiferous gland

molar

parotid gland

right ventricle

embryo

lacrimal gland

muscle of thigh

olfactory epithelium

vestibular sensory epithelium

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding molecular function
Cellular component	extracellular region extracellular space
Biological process	protein stabilization lactation transmembrane transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


1448


12994

Ensembl


ENSG00000171209


ENSMUSG00000001622

UniProt


P07498


P06796

RefSeq (mRNA)


NM_005212 NM_001394997


NM_007786 NM_001356570 NM_001356571

RefSeq (protein)


NP_005203


NP_031812 NP_001343499 NP_001343500

Location (UCSC)

Chr 4: 70.24 – 70.25 Mb

Chr 5: 88.07 – 88.08 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

CSN3 (gene) has been shown to interact with EIF3S6.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171209 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001622 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Edlund A, Johansson T, Leidvik B, Hansson L (Nov 1996). "Structure of the human kappa-casein gene". Gene. 174 (1): 65–9. doi:10.1016/0378-1119(96)00351-4. PMID 8863730.
^ Fujiwara Y, Miwa M, Nogami M, Okumura K, Nobori T, Suzuki T, Ueda M (Mar 1997). "Genomic organization and chromosomal localization of the human casein gene family". Hum Genet. 99 (3): 368–73. doi:10.1007/s004390050374. PMID 9050925. S2CID 8299892.
^ "Entrez Gene: CSN3 casein kappa".
^ Hoareau Alves, Karine; Bochard Valérie; Réty Stéphane; Jalinot Pierre (Sep 2002). "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome". FEBS Lett. 527 (1–3). Netherlands: 15–21. doi:10.1016/S0014-5793(02)03147-2. ISSN 0014-5793. PMID 12220626. S2CID 39308598.

Human CSN3 genome location and CSN3 gene details page in the UCSC Genome Browser.

Bergström S, Hansson L, Hernell O, et al. (1993). "Cloning and sequencing of human kappa-casein cDNA". DNA Seq. 3 (4): 245–6. doi:10.3109/10425179209034024. PMID 1296818.
Brignon G, Chtourou A, Ribadeau-Dumas B (1985). "Preparation and amino acid sequence of human kappa-casein". FEBS Lett. 188 (1): 48–54. doi:10.1016/0014-5793(85)80872-3. PMID 4018271. S2CID 83551753.
Fiat AM, Jollès J, Aubert JP, et al. (1981). "Localisation and importance of the sugar part of human casein". Eur. J. Biochem. 111 (2): 333–9. doi:10.1111/j.1432-1033.1980.tb04946.x. PMID 7460900.
Plowman JE, Creamer LK, Liddell MJ, Cross JJ (1999). "Structural features of a peptide corresponding to human kappa-casein residues 84-101 by 1H-nuclear magnetic resonance spectroscopy". J. Dairy Res. 66 (1): 53–63. doi:10.1017/S0022029998003318. PMID 10191473. S2CID 22589486.
Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
Benítez MJ, Cochet C, Jiménez JS (2002). "A surface plasmon resonance study of the interactions between the component subunits of protein kinase CK2 and two protein substrates, casein and calmodulin". Mol. Cell. Biochem. 227 (1–2): 31–6. doi:10.1023/A:1013140220121. PMID 11827172. S2CID 19295218.
Sood SM, Slatter CW (2003). "Suspension of the calcium-sensitive human beta-caseins by human kappa-casein". J. Dairy Sci. 85 (6): 1353–6. doi:10.3168/jds.S0022-0302(02)74200-8. PMID 12146463.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kim YJ, Park S, Oh YK, et al. (2005). "Purification and characterization of human caseinomacropeptide produced by a recombinant Saccharomyces cerevisiae". Protein Expr. Purif. 41 (2): 441–6. doi:10.1016/j.pep.2005.02.021. PMID 15866733.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.