DDO (gene)

D-aspartate oxidase is an enzyme that is encoded by the DDO gene.^[5][6]

DDO
Identifiers
Aliases	DDO, Ddo, 5330420D20Rik, 5730402C02Rik, AI467244, DASOX, DDO-1, DDO-2, D-aspartate oxidase
External IDs	OMIM: 124450; MGI: 1925528; HomoloGene: 101531; GeneCards: DDO; OMA:DDO - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q21 Start 110,391,771 bp[1] End 110,415,562 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B1 Start 40,506,007 bp[2] End 40,557,843 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ventricle apex of heart right ventricle myocardium myocardium of left ventricle right adrenal gland right adrenal cortex right auricle left adrenal gland kidney tubule Top expressed in Ependyma of ventricular system of brain digastric muscle sternocleidomastoid muscle right kidney temporal muscle triceps brachii muscle soleus muscle parotid gland Epithelium of choroid plexus myocardium of ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity FAD binding signaling receptor binding protein binding D-amino-acid oxidase activity D-aspartate oxidase activity Cellular component peroxisome peroxisomal matrix cytosol cytoplasm Biological process insemination grooming behavior aspartate metabolic process D-amino acid metabolic process hormone metabolic process aspartate catabolic process D-amino acid catabolic process cellular nitrogen compound metabolic process protein targeting to peroxisome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8528 70503 Ensembl ENSG00000203797 ENSMUSG00000063428 UniProt Q99489 Q922Z0 RefSeq (mRNA) NM_003649 NM_004032 NM_027442 NM_001316716 NM_001316717 NM_001316718 NM_001316719 RefSeq (protein) NP_004023 NP_001355099 NP_001355100 NP_001355101 NP_001355102 NP_001355103 NP_001355104 NP_001359037 NP_001303645 NP_001303646 NP_001303647 NP_001303648 NP_081718 Location (UCSC) Chr 6: 110.39 – 110.42 Mb Chr 10: 40.51 – 40.56 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a peroxisomal flavoprotein that catalyzes the oxidative deamination of D-aspartate and N-methyl D-aspartate. Flavin adenine dinucleotide or 6-hydroxyflavin adenine dinucleotide can serve as the cofactor in this reaction. Two (or four, according to Q99489) transcript variants encoding different isoforms have been found for this gene.^[6]