DYNLT1

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Dynein light chain Tctex-type 1 is a protein that in humans is encoded by the DYNLT1 gene.^[5]^[6]^[7]

DYNLT1

Identifiers

Aliases

DYNLT1, CW-1, TCTEL1, tctex-1, dynein light chain Tctex-type 1, TCTEX1

External IDs

OMIM: 601554; MGI: 98643; HomoloGene: 4754; GeneCards: DYNLT1; OMA:DYNLT1 - orthologs

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	6q25.3	Start	158,636,474 bp^[1]
Band	6q25.3	End	158,644,743 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)^[2]

Band	17 A1\|17 3.97 cM	Start	6,697,511 bp^[2]
Band	17 A1\|17 3.97 cM	End	6,703,695 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

bronchial epithelial cell

epithelium of nasopharynx

olfactory zone of nasal mucosa

palpebral conjunctiva

nasal epithelium

oral cavity

ganglionic eminence

islet of Langerhans

jejunal mucosa

mucosa of paranasal sinus

Top expressed in

spermatid

spermatocyte

neural tube

mesencephalon

lens

testicle

islet of Langerhans

granulocyte

epiblast

urinary bladder

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding identical protein binding cytoskeletal motor activity protein C-terminus binding
Cellular component	cytoplasm Golgi apparatus secretory vesicle spindle dynein complex cytoplasmic microtubule microtubule cytoskeleton host cell extracellular region cytoplasmic dynein complex secretory granule lumen ficolin-1-rich granule lumen mitochondrion lamellipodium neuronal cell body axonal growth cone
Biological process	intracellular transport of viral protein in host cell regulation of G protein-coupled receptor signaling pathway negative regulation of neurogenesis nervous system development cell division establishment of mitotic spindle orientation microtubule-dependent intracellular transport of viral material towards nucleus viral entry into host cell cell cycle viral process transport of viral material towards nucleus neutrophil degranulation positive regulation of neuron projection development dendrite development positive regulation of Rac protein signal transduction negative regulation of mitochondrial membrane permeability regulation of GTPase activity neuron projection morphogenesis regulation of cytoskeleton organization negative regulation of cell death axon development
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6993


21648

Ensembl


ENSG00000146425


ENSMUSG00000096255

UniProt


P63172


P51807

RefSeq (mRNA)


NM_006519 NM_001291602 NM_001291603


NM_009342

RefSeq (protein)


NP_001278531 NP_001278532 NP_006510


NP_001160099 NP_001186877 NP_001160102 NP_001160101 NP_033368

Location (UCSC)

Chr 6: 158.64 – 158.64 Mb

Chr 17: 6.7 – 6.7 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Cytoplasmic dynein is the major motor protein complex responsible for minus-end, microtubule-based motile processes. Each dynein complex consists of 2 heavy chains that have ATPase and motor activities, plus a group of accessory polypeptides. TCTEX1 is a dynein light chain involved in cargo binding (Chuang et al., 2005).[supplied by OMIM]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000146425 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000096255 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Watanabe TK, Fujiwara T, Shimizu F, Okuno S, Suzuki M, Takahashi E, Nakamura Y, Hirai Y (Jul 1996). "Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to 6q". Cytogenet Cell Genet. 73 (1–2): 153–6. doi:10.1159/000134329. PMID 8646886.
^ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502.
^ ^a ^b "Entrez Gene: DYNLT1 dynein, light chain, Tctex-type 1".

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King SM, Dillman JF, Benashski SE, et al. (1997). "The mouse t-complex-encoded protein Tctex-1 is a light chain of brain cytoplasmic dynein". J. Biol. Chem. 271 (50): 32281–7. doi:10.1074/jbc.271.50.32281. PMID 8943288.
Nagano F, Orita S, Sasaki T, et al. (1998). "Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport". J. Biol. Chem. 273 (46): 30065–8. doi:10.1074/jbc.273.46.30065. PMID 9804756.
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Mueller S, Cao X, Welker R, Wimmer E (2002). "Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis". J. Biol. Chem. 277 (10): 7897–904. doi:10.1074/jbc.M111937200. PMID 11751937.
Schwarzer C, Barnikol-Watanabe S, Thinnes FP, Hilschmann N (2002). "Voltage-dependent anion-selective channel (VDAC) interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74". Int. J. Biochem. Cell Biol. 34 (9): 1059–70. doi:10.1016/S1357-2725(02)00026-2. PMID 12009301. S2CID 11632830.
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Machado RD, Rudarakanchana N, Atkinson C, et al. (2004). "Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension". Hum. Mol. Genet. 12 (24): 3277–86. doi:10.1093/hmg/ddg365. PMID 14583445.
Douglas MW, Diefenbach RJ, Homa FL, et al. (2004). "Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport". J. Biol. Chem. 279 (27): 28522–30. doi:10.1074/jbc.M311671200. PMID 15117959.
Ohka S, Matsuda N, Tohyama K, et al. (2004). "Receptor (CD155)-dependent endocytosis of poliovirus and retrograde axonal transport of the endosome". J. Virol. 78 (13): 7186–98. doi:10.1128/JVI.78.13.7186-7198.2004. PMC 421661. PMID 15194795.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
de Wit NJ, Verschuure P, Kappé G, et al. (2005). "Testis-specific human small heat shock protein HSPB9 is a cancer/testis antigen, and potentially interacts with the dynein subunit TCTEL1". Eur. J. Cell Biol. 83 (7): 337–45. doi:10.1078/0171-9335-00396. PMID 15503857.
Chuang JZ, Yeh TY, Bollati F, et al. (2005). "The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth". Dev. Cell. 9 (1): 75–86. doi:10.1016/j.devcel.2005.04.003. PMC 3857739. PMID 15992542.
Yeh TY, Peretti D, Chuang JZ, et al. (2007). "Regulatory dissociation of Tctex-1 light chain from dynein complex is essential for the apical delivery of rhodopsin". Traffic. 7 (11): 1495–502. doi:10.1111/j.1600-0854.2006.00482.x. PMC 3873093. PMID 16956385.