Immunosurveillance and immunoregulation by gammadelta T cells - PubMed
Michael Girardi 1
Article ImagesReview
Immunosurveillance and immunoregulation by gammadelta T cells
Michael Girardi. J Invest Dermatol. 2006 Jan.
Free article
Abstract
Whereas the vast majority of T cells express a T-cell receptor (TCR) composed of alphabeta heterodimers, a smaller population expresses a gammadelta TCR. In contrast to alphabeta T cells, gammadelta T cells show less TCR diversity, are particularly enriched at epithelial surfaces and appear to respond to self-molecules that signal potential danger or cellular stress. In addition, various subsets of gammadelta T cells have shown antitumor and immunoregulatory activities. This review considers what has been discovered about the important cutaneous functions of gammadelta T cells through the study of mutant mice and offers perspectives on the roles of gammadelta T cells in human disease.
Similar articles
-
Cutaneous biology of gammadelta T cells.
Girardi M. Girardi M. Adv Dermatol. 2004;20:203-15. Adv Dermatol. 2004. PMID: 15544201 Review.
-
Hiasa A, Nishikawa H, Hirayama M, Kitano S, Okamoto S, Chono H, Yu SS, Mineno J, Tanaka Y, Minato N, Kato I, Shiku H. Hiasa A, et al. Gene Ther. 2009 May;16(5):620-8. doi: 10.1038/gt.2009.6. Epub 2009 Feb 26. Gene Ther. 2009. PMID: 19242528
-
Leandersson K, Jaensson E, Ivars F. Leandersson K, et al. Immunology. 2006 Sep;119(1):134-42. doi: 10.1111/j.1365-2567.2006.02415.x. Immunology. 2006. PMID: 16925528 Free PMC article.
-
Differential Ly49e expression pathways in resting versus TCR-activated intraepithelial γδ T cells.
Van Den Broeck T, Van Ammel E, Delforche M, Taveirne S, Kerre T, Vandekerckhove B, Taghon T, Plum J, Leclercq G. Van Den Broeck T, et al. J Immunol. 2013 Mar 1;190(5):1982-90. doi: 10.4049/jimmunol.1200354. Epub 2013 Jan 21. J Immunol. 2013. PMID: 23338239
-
Gammadelta T cells: functional plasticity and heterogeneity.
Carding SR, Egan PJ. Carding SR, et al. Nat Rev Immunol. 2002 May;2(5):336-45. doi: 10.1038/nri797. Nat Rev Immunol. 2002. PMID: 12033739 Review.
Cited by
-
Extracellular vesicles mediated gastric cancer immune response: tumor cell death or immune escape?
Yang S, Wei S, Wei F. Yang S, et al. Cell Death Dis. 2024 May 30;15(5):377. doi: 10.1038/s41419-024-06758-8. Cell Death Dis. 2024. PMID: 38816455 Free PMC article. Review.
-
Mohamed AA, Al-Ramadi BK, Fernandez-Cabezudo MJ. Mohamed AA, et al. Int J Mol Sci. 2024 Feb 1;25(3):1747. doi: 10.3390/ijms25031747. Int J Mol Sci. 2024. PMID: 38339023 Free PMC article. Review.
-
Zhang W, Xu X, Zhang R, Tian Y, Ma X, Wang X, Jiang Y, Man C. Zhang W, et al. Animals (Basel). 2024 Jan 10;14(2):225. doi: 10.3390/ani14020225. Animals (Basel). 2024. PMID: 38254394 Free PMC article.
-
Dendritic Cell-Based Immunity: Screening of Dendritic Cell Subsets in Breast Cancer-Bearing Mice.
Aldahlawi AM, Zaher KSA. Aldahlawi AM, et al. J Microsc Ultrastruct. 2023 Jan 19;11(3):150-160. doi: 10.4103/jmau.jmau_85_22. eCollection 2023 Jul-Sep. J Microsc Ultrastruct. 2023. PMID: 38025181 Free PMC article.
-
Mathematical Characterization of Private and Public Immune Receptor Sequences.
Böttcher L, Wald S, Chou T. Böttcher L, et al. Bull Math Biol. 2023 Sep 14;85(10):102. doi: 10.1007/s11538-023-01190-z. Bull Math Biol. 2023. PMID: 37707621 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical